from Science News Online
Warming to a Cold War Herb
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Growing at high altitudes from Scandinavia to Siberia, rhodiola has for centuries been a part of folk medicine among diverse native groups. Documented medicinal use reaches back at least to A.D. 77, when a physician to Roman legionnaires recommended it for headaches. In the 18th century, Linnaeus gave the herb its scientific name.
Soviet-government scientists Nikolai Lazarev and Israel Brekhman knew of this traditional use when, after World War II, they launched an extensive program to boost Soviet competitiveness in athletics and other demanding fields. The scientists tested nearly 200 herbal folk remedies and found 5, including rhodiola, particularly intriguing. They called the plants adaptogens for their ability to foster increased resistance to stress and to boost physical and mental performance. Unlike amphetamines, which the postwar Soviets also tested, these plants weren’t addictive, and users didn’t “crash” or suffer a rebound period of profound fatigue.
The adaptogens performed well on a pivotal test invented by the Soviets, an endurance swim for rats. When plopped into water, a rat will swim steadily for 10 to 15 minutes. Then it will float, paddling only as needed to keep from drowning. When the Soviet scientists gave rats rhodiola, the animals swam 35 percent to 59 percent longer. A modified version of the test is still used by academic researchers and drug companies to screen for potential new antidepressants.
By 1969, Soviet scientists had amassed enough evidence for the Ministry of Health to recommend rhodiola in its official list of medicines. Use of the herb took off.
“The Soviets were really invested in it,” says Georg Wikman of the Swedish Herbal Institute in Göteborg, who studies the herb. “There must be 300 to 400 reports published in quite good Russian-language journals.”
Much of the Soviet research on the herb remains untranslated or locked away because authorities considered adaptogen research a “top military secret,” Ramazanov maintained before his death last year. Nevertheless, he had translated some key findings by that time. In animals, the herb lowers production of the stress hormone cortisol. It acts as an antioxidant, helping to eliminate from the body the oxygen radicals that damage cells. And in muscles, it increases production of adenosine triphosphate, the molecule that serves as cellular gasoline.
Trials in people, while not up to Western standards, hinted that rhodiola could alleviate depression, erectile dysfunction and premature ejaculation, and chronic listlessness.
Other, higher quality trials suggested that the herb could boost athletic performance. A trial run by Victor Baranov at Moscow’s Institute for Space Medicine in the 1990s found that after taking rhodiola, inactive adults performed just as well as trained athletes in aerobic tests. During that experiment, researchers randomly assigned volunteers to take either the herb or a placebo, and participants, as well as their testers, were blind to which was which. Around the same time, another such randomized, double-blind study of 42 male biathletes reported improved target shooting in the group that took the herb. Also, the extract seemed to speed recovery of the athletes’ circulatory systems. Thirty minutes after the skiing part of the biathlon, the hearts of those who took the extract were beating at 105 percent of prerace rates, compared with 129 percent of precompetition rates among athletes who took a placebo.
In the late 1980s, researchers at the Russian Academy of Sciences in Moscow, home to much of the adaptogen work, discovered that three compounds found only in the rosea type of Rhodiola—there are at least 200 related species—were responsible for much of the plant’s activity. They dubbed these compounds rosavins, and in 1989 the Soviet government declared that all rhodiola extracts must contain at least 3 percent rosavins. Dietary supplement makers throughout the world still hew to this standard.
Even before the discovery of rosavins, Soviet adaptogen research culminated with ADAPT, a mixture of extracts from R. rosea, a species of ginseng, and a berry called Schizandra chinensis. Hoping for a synergistic effect, the Soviets gave ADAPT to Olympic athletes, according to Ramazanov’s self-published material.
The Soviets then decided to test ADAPT in their space program, a plan that enlisted Wikman and the Swedish Herbal Institute. Wikman and the Soviet scientists gave ADAPT to 60 sleep-deprived cosmonaut trainees. “Those tests went well,” says Wikman. The mixture “had a very clear effect on mental-work capacity, problem solving, and short-term memory when the subjects were really, really tired after staying up for days.” The mixture also helped normalize an elaborate measure of cardiac function in the sleep-deprived trainees. “So the decision was made to take it up, use it in space,” Wikman says.
Cosmonaut Valery Polyakov, a physician, took ADAPT daily while commander of the Mir space station during his 14-month mission in 1994 and 1995, says Wikman. Wikman adds that Polyakov credited ADAPT with helping him endure the record-length spaceflight.
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Since the turn of the century, a growing number of reports investigating rhodiola have appeared in English-language journals. Several groups of researchers have found that, in the laboratory, rhodiola inhibits the spread of bacteria, prevents immune system damage caused by anticancer drugs, slows the division of cancer cells, and corrects enzyme irregularities in diabetic mice.
Meanwhile, Wikman and the Swedish Herbal Institute, which makes a rhodiola extract called SHR-5, have continued laboratory and human tests. In 2000, they reported that SHR-5 protects snail embryos from heat, copper, and oxidative stress. When given the herb extract, fewer of the embryos died after exposure to these stressors than did embryos not given the extract.
Also in 2000, Wikman and his colleagues in Russia published results from a randomized, double-blind trial of university students who took SHR-5 at the end of a semester. Students taking the herb for 20 days fared better on measures of fatigue and mental performance than did students who took a placebo. Another study published in 2000 found an antifatigue effect of the herb among 56 physicians working night shifts.
In 2003, the Swedish-Russian group published a study of 100 male military cadets who took a single dose of SHR-5. After working all night, 40 cadets received a low dose of the extract, 40 a high dose, and 20 a placebo. The cadets taking either dose of the extract scored higher on a battery of concentration and mental-performance tests than did cadets taking the placebo.
Most recently, in the September-October Nordic Journal of Psychiatry, Wikman and coworkers in Armenia report a randomized, double-blind trial in people with mild-to-moderate depression. For 6 weeks, two groups of 30 patients took either of two doses of SHR-5 while a third group took a placebo. People taking either dose of the extract reported fewer symptoms on standard depression questionnaires at the end of the study than did those who took the placebo.
“I’ve been using it as an antidepressant for years now,” says Columbia University’s Brown. “But it’s nice to have that validated in a clinical trial.”